APPLICATIONS

Health Care

Whether early stage discovery or screening current patient populations, the need for novel discovery in medical research and healthcare is immense.

At HMT we provide a collaborative atmosphere working with our clients to find solutions by utilizing the maximum potential of our current platforms and working with our clients to drive new technology development at HMT.

Biomarker Discovery

  • Lipidomics option

  • Untargeted Profiling

  • Statistical and Pathway Analysis

  • Deep Dive metabolomics

  • Quantitative option

  • Novel metabolites

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Pharma/Biotech

The Pharmaceutical and Biotech industry utilizes metabolomics in a number of key areas in their drug research and development pipelines.

Pre-clinical use of cell lines, bioassays and animal models use metabolomics to validate target engagement, search for markers of disease progression and much more.

Clinical studies use retroactive / prospective samples from biorepositories or from on-going clinical studies with metabolomic profiles to help find early biomarkers of disease or understand patient stratification.

Untargeted Discovery

  • Lipidomics Option

  • Untargeted Profiling

  • Statistical and Pathway Analysis

  • Deep Dive Metabolomics

  • Quantitative Option

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Cancer Metabolism

One of the most significant hallmarks of cancer is it’s dependence on high levels of glucose and an impaired respiratory capacity despite the presence of oxygen, often termed the Warburg Effect. While most cancers do rely heavily on glucose supply, recent years has shown that cancer cells maintain a high level of metabolic flexibility.

Today’s research is focused on how cancer cells produce the energy that is needed for such like glucose and glutamine, and which metabolic pathways are essential to survival and therefore potential therapeutic targets.

Quantitative Profiling

  • Targeted analysis of 116 metabolites

  • Redox status, Urea cycle

  • Uncover Warburg effects and energy imbalance

  • Glycolysis, Glutaminolysis

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Food and Nutrition

Profiling of nutrient and bio-functional compounds can provide indicators supporting the development and quality control of food and nutritional products.

Based on the quantitative measurement of hundreds of food-based metabolites, HMT can propose novel assessments supporting productivity improvements for agriculture, fermentation and bioprocessing. In addition, the discovery of novel bio-functional compounds can add new value to products focusing on healthcare markets.

Untargeted Discovery

  • Lipidomics included

  • Untargeted Profiling

  • Statistical and Pathway Analysis

  • Deep Dive metabolomics

  • Quantitative option

  • Available for a variety of samples

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Flux Analysis

Progress to understanding in vivo metabolomics: C13 Isotope studies.

One key to understanding cellular metabolomics lies in the ability to accurately determine the specific metabolic pathways that are employed. Steady state metabolomics is an easy way to initially understand the metabolic needs of metabolic needs of cells and tissues.

C13 isotope analyses are a very useful tool for following the fates of nutrients inside the cell. In vitro experiments are easy to perform and can yield valuable insights. The push towards in vivo C13 labeling will allow researchers to confirm the cells preferred metabolic pathways and better understand druggable targets.

HMT is committed to providing our unique C13 analyses for cultured cells, as well as, in the in vivo setting.

C13 Isotope Tracing

  • Use C13 substrates to determine nutrient processing
  • Uncover novel mechanisms for cell survival or apoptosis

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