One of the most significant hallmarks of cancer is it’s dependence on high levels of glucose and an impaired respiratory capacity despite the presence of oxygen, often termed the Warburg Effect. While most cancers do rely heavily on glucose supply, recent years has shown that cancer cells maintain a high level of metabolic flexibility.
Today’s research is focused on how cancer cells produce the energy that is needed for such rapid proliferation on substrates like glucose and glutamine. Which metabolic pathways are essential to survival and therefore potential therapy targets?
Click to see some of our recent publications in Oncology.