Health Care

Diabetes / Obesity

  • L-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2.
    Nakatsu D., et al., Proc. Natl. Acad. Sci. U. S. A., 112:E1067-1076, 2015.

  • Wheat Alkylresorcinols Suppress High-Fat, High-Sucrose Diet-Induced Obesity and Glucose Intolerance by Increasing Insulin Sensitivity and Cholesterol Excretion in Male Mice.
    Oishi K., et al., J. Nutr., 145, 199-206, 2015.

  • Possible Contribution of Taurine to Distorted Glucagon Secretion in Intra-Islet Insulin Deficiency: A Metabolome Analysis Using a Novel α-Cell Model of Insulin-Deficient Diabetes.
    Bessho M., et al., PLoS One, 9:e113254, 2014.

  • Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice.
    Hirotsu Y., et al., Genes Cells, 19, 650-665, 2014.

  • Remodeling of hepatic metabolism and hyperaminoacidemia in mice deficient in proglucagon-derived peptides.
    Watanabe C., et al., Diabetes, 61, 74-84, 2012.

Hepatitis / Liver dysfunction

  • Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis.
    Goto M., et al., Genes Cells, 20, 464-480, 2015.

  • Transcription Factor Nrf1 Negatively Regulates the Cystine/Glutamate Transporter and Lipid-Metabolizing Enzymes.
    Tsujita T., et al., Mol. Cell. Biol., 34, 3800-3816, 2014.

  • L-carnitine prevents progression of non-alcoholic steatohepatitis in a mouse model with upregulation of mitochondrial pathway.
    Ishikawa H., et al., PLoS One, 9:e100627, 2014.

  • Plasma amino acids imbalance in cirrhotic patients disturbs the tricarboxylic acid cycle of dendritic cell.
    Kakazu E., et al., Sci. Rep., 3:3459, 2013.

  • Serum metabolomic profile and potential biomarkers for severity of fibrosis in nonalcoholic fatty liver disease.
    Tokushige K., et al., J .Gastroenterol., 48,1392-1400, 2013.

  • NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes.
    Hirotsu Y., et al., Mol. Cell Biol., 32, 2760-2770, 2012.

Cardiovascular disease

  • Excessive degradation of adenine nucleotides by up-regulated AMP deaminase underlies afterload-induced diastolic dysfunction in the type 2 diabetic heart.
    Kouzu H., et al., J. Mol. Cell Cardiol., 80, 136-145, 2015.

  • Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice.
    Nakatani K., et al., Metabolism, 64, 1165-1174, 2015.

  • Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage.
    Yamashita A., et al., PLoS One, 9:e86426, 2014.

  • Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy.
    Maekawa K., et al., J. Mol. Cell Cardiol. 59, 76-85, 2013.

  • Metabolomic anatomy of an animal model revealing homeostatic imbalances in dyslipidemia.
    Ooga T., et al., Mol. Biosyst., 7, 1217-1223, 2011.

Infection disease

  • Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus.
    Sugiyama K., et al., PLoS One, 9:e94460, 2014.

  • Erythritol alters microstructure and metabolomic profiles of biofilm composed of Streptococcus gordonii and Porphyromonas gingivalis.
    Hashino E., et al., Mol. Oral. Microbiol., 28, 435-451, 2013.

  • Dramatic Increase in Glycerol Biosynthesis upon Oxidative Stress in the Anaerobic Protozoan Parasite Entamoeba histolytica.
    Husain A., et al., PLoS Negl. Trop. Dis., 6:e1831, 2012.

  • Metabolomic effects of xylitol and fluoride on plaque biofilm in vivo.
    Takahashi N., et al., J. Dent. Res., 90, 1463-1468, 2011.

  • Hepatitis C Virus Infection Promotes Hepatic Gluconeogenesis through an NS5A-Mediated, FoxO1-Dependent Pathway.
    Deng L., et al., J. Virol., 85, 8556-8568, 2011.

Other disease

  • Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder.
    Ogawa S., et al., Sci. Rep., 5:7796, 2015.

  • Plasma and Liver Metabolic Profiles in Mice Subjected to Subchronic and Mild Social Defeat Stress.
    Goto T., et al., J. Proteome Res., 14, 1025-1032, 2015.

  • Disease modifying effect of adiponectin in model of α-synucleinopathies.
    Sekiyama K., et al., Ann. Clin. Transl. Neurol., 1, 479-489, 2014.

  • A snapshot of plasma metabolites in first-episode schizophrenia: a capillary electrophoresis time-of-flight mass spectrometry study.
    Koike S., et al., Transl. Psychiatry, 4:e379, 2014.

  • Altered Metabolites in the Plasma of Autism Spectrum Disorder: A Capillary Electrophoresis Time-of-Flight Mass Spectroscopy Study.
    Kuwabara H., et al., PLoS One, 8:e73814, 2013.

  • Metabolomic analysis reveals hepatic metabolite perturbations in citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mice, a model of human citrin deficiency.
    Saheki T., et al., Mol. Genet Metab., 104, 492-500, 2011.

Stem cell / Regenerative medicine

  • Hypothermic temperature effects on organ survival and restoration.
    Ishikawa J., et al., Sci. Rep., 5:9563, 2015.

  • Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells.
    Konno M., et al., Regen. Therapy, 1, 63-71, 2015.

  • DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway.
    Nishikawa K., et al., Nat. Med., 21, 281-287, 2015.

  • Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1.
    Baba T., et al., Nat. Commun., 5:3634, 2014.

  • CCN2 as a Novel Molecule Supporting Energy Metabolism of Chondrocytes.
    Maeda-Uematsu A., et al., J. Cell Biochem., 115, 854-865, 2014.

  • Vascularized and functional human liver from an iPSC-derived organ bud transplant.
    Takebe T., et al., Nature, 499, 481-484, 2013.

  • Metabolomic analysis of differential changes in metabolites during ATP oscillations in chondrogenesis.
    Kwon HJ., et al., Biomed. Res. Int., 2013:213972, 2013.

  • Synchronized ATP oscillations have a critical role in prechondrogenic condensation during chondrogenesis.
    Kwon HJ., et al., Cell Death. Dis., 3:e278, 2012.

  • Rhythmic Nucleotide Synthesis in the Liver: Temporal Segregation of Metabolites.
    Fustin JM., et al., Cell Rep., 1, 341-349, 2012.


  • Antipruritic effects of the probiotic strain LKM512 in adults with atopic dermatitis.
    Matsumoto M., et al., Ann. Allergy Asthma. Immunol., 113, 209-216, 2014.

  • Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice.
    Kibe R., et al., Sci. Rep., 4:4548, 2014.

  • Cerebral low-molecular metabolites influenced by intestinal microbiota: a pilot study.
    Matsumoto M., et al., Front Syst. Neurosci., 7:9, 2013.

  • Impact of Intestinal Microbiota on Intestinal Luminal Metabolome.
    Matsumoto M., et al., Sci. Rep., 2:233, 2012.


  • Manual therapy ameliorates delayed‐onset muscle soreness and alters muscle metabolites in rats.
    Urakawa S., et al., Physiol. Rep., 3:e12279, 2015.

  • Non-targeted human plasma metabolomics reveals the changes in oleoylethanolamide, a lipid-derived signaling molecule, by acute exposure of electric field.
    Nakagawa-Yagi N., et al., Integr. Mol. Med, 1, 29-37, 2014

  • Metabolomics of salivary fatigue markers in soccer players after consecutive games.
    Ra SG., et al., Appl. Physiol. Nutr. Metab., 39, 1120-1126, 2014.

  • Effects of pH and lactate on hydrogen sulfide production by oral Veillonella spp.
    Washio J., et al., Appl. Environ Microbiol., 80, 4184-4188, 2014.


  • Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile.
    Kuroda K., et al., Int. J. Oncol., 46, 1516-1526, 2015.

  • Identification of Metabolic Signatures Associated with Erlotinib Resistance of Non-small Cell Lung Cancer Cells.
    Serizawa M., et al., Anticancer Res., 34, 2779-2787, 2014.

  • CD133-positive cancer stem cells from Colo205 human colon adenocarcinoma cell line show resistance to chemotherapy and display a specific metabolomic profile.
    Vincent Z., et al., Genes Cancer, 5, 250-260, 2014.

  • Inhibition of ATP Citrate Lyase Induces an Anticancer Effect via Reactive Oxygen Species: AMPK as a Predictive Biomarker for Therapeutic Impact.
    Migita T., et al., Am. J. Pathol., 182, 1800-1810, 2013.

  • The effect of acyclic retinoid on the metabolomic profiles of hepatocytes and hepatocellular carcinoma cells.
    Qin XY., et al., PLoS One, 8:e82860, 2013.

  • Metabolomic analysis revealed glycylglycine accumulation in astrocytes after methionine enkephalin administration exhibiting neuron protective effects.
    Zhao C., et al., J. Pharm. Biomed. Anal., 115, 48-54, 2015.

Cancer Metabolism

  • SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
    Kim D., et al., Nature. 520, 363-367, 2015.

  • Lysine demethylase LSD1 coordinates glycolytic and mitochondrial metabolism in hepatocellular carcinoma cells.
    Sakamoto A., et al., Cancer Res., 75, 1445-1456, 2015.

  • The drs tumor suppressor regulates glucose metabolism via lactate dehydrogenase-B.
    Tambe Y., et al., Mol. Carcinog., 2015.

  • Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in human gastric cancer.
    Hosoda F., et al., Oncogene, 34, 1196-1206, 2015.

  • Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells.
    Takebayashi S., et al., Aging Cell, 14, 689-697, 2015.

  • Hsa-miR-520d induces hepatoma cells to form normal liver tissues via a stemness-mediated process.
    Tsuno S., et al., Sci. Rep., 4:3852, 2014.

  • Epidermal Growth Factor Receptor (EGFR) Signaling Regulates Global Metabolic Pathways in EGFR-mutated Lung Adenocarcinoma.
    Makinoshima H., et al., J. Biol. Chem., 289, 20813-20823, 2014.

  • Glucose and glutamine metabolism in oral squamous cell carcinoma: insight from a quantitative metabolomic approach.
    Ogawa T., et al. Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol., 118, 218-225, 2014.

  • Leukemia cells demonstrate a different metabolic perturbation provoked by 2-deoxyglucose.
    Miwa H., et al., Oncol. Rep., 29, 2053-2057, 2013.

  • Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry.
    Kami K., et al., Metabolomics, 9, 444-453, 2013.

  • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome.
    Yoshimoto S., et al., Nature, 499, 97-101, 2013.

Food and Nutrition

Food Science

  • Metabolomic Analysis of Blood Plasma after Oral Administration of N-acetyl-d-Glucosamine in Dogs.
    Osaki T., et al., Mar. Drugs, 13, 5007-5015, 2015.

  • Sphingosine 1-phosphate lyase inhibition by 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) under conditions of vitamin B6 deficiency.
    Ohtoyo M., et al., Mol. Cell Biochem., 400, 125-133, 2015.

  • Regulation of free glutamate content in meat by dietary lysine in broilers.
    Watanabe G., et al., Anim. Sci. J., 86, 435-442, 2015.

  • Multi-faceted integrated omics analysis revealed parsley (Petroselinum crispum) as a novel dietary intervention in dextran sodium sulphate induced colitic mice.
    Jia H., et al., J. Func. Food, 11, 438–448, 2014.

  • An Integrated Multi-Omics Study Revealed Metabolic Alterations Underlying the Effects of Coffee Consumption.
    Takahashi S., et al., PLoS One, 9:e91134, 2014.

  • CE-TOF MS-based metabolomic profiling revealed characteristic metabolic pathways in postmortem porcine fast and slow type muscles.
    Muroya S., et al., Meat Sci., 98, 726-735, 2014.

  • Metabolomic analyses of blood plasma after oral administration of D-glucosamine hydrochloride to dogs.
    Osaki T., et al., Mar. Drugs, 10, 1873-1882, 2012.

  • Metabolomics analysis of Cistus monspeliensis leaf extract on energy metabolism activation in human intestinal cells.
    Shimoda Y., et al., J. Biomed. Biotechnol., 2012:428514, 2012.

  • Characterization of volatile and non-volatile metabolites in etiolated leaves of tea (Camellia sinensis) plants in the dark.
    Yang Z., et al., Food Chem., 135, 2268-2276, 2012.


  • Regulation of Primary Metabolic Pathways in Oyster Mushroom Mycelia Induced by Blue Light Stimulation: Accumulation of Shikimic Acid.
    Kojima M., et al., Sci. Rep., 5:8630, 2015.

  • Study of polar metabolites in tobacco from different geographical origins by using capillary electrophoresis–mass spectrometry.
    Zhao J., et al., Metabolomics, 10, 805-815, 2014.

  • Hormones, polyamines, and cell wall metabolism during oil palm fruit mesocarp development and ripening.
    Teh HF., et al., J. Agric. Food Chem., 62, 8143-8152, 2014.

  • Profiling of Metabolites in Oil Palm Mesocarp at Different Stages of Oil Biosynthesis.
    Neoh BK., et al., J. Agric. Food Chem., 61, 1920-1927, 2013.

  • Differential Metabolite Profiles during Fruit Development in High-Yielding Oil Palm Mesocarp.
    Teh HF., et al., PLoS One, 8:e61344, 2013.

  • Autophagy contributes to night-time energy availability for growth in Arabidopsis.
    Izumi M., et al., Plant Physiol., 161, 1682-1693, 2013.

  • Deficiency of autophagy leads to significant changes of metabolic profiles in Arabidopsis.
    Izumi M., et al., Plant Signal Behav., 8:e25023, 2013.

  • Metabolome analysis of photosynthesis and the related primary metabolites in the leaves of transgenic rice plants with increased or decreased Rubisco content.
    Suzuki Y., et al., Plant Cell Environ., 35, 1369-1379, 2012.

Industry / Fermentation

  • Bacterial pyruvate production from alginate, a promising carbon source from marine brown macroalgae.
    Kawai S., et al., J. Biosci. Bioeng., 117, 269-274, 2014.

  • Fermentation of Xylose Causes Inefficient Metabolic State Due to Carbon/Energy Starvation and Reduced Glycolytic Flux in Recombinant Industrial Saccharomyces cerevisiae.
    Matsushika A., et al., PLoS One, 8:e69005, 2013.

  • Metabolic and morphological changes of an oil accumulating trebouxiophycean alga in nitrogen-deficient conditions.
    Ito T., et al., Metabolomics, 9, 178-187, 2013.

  • Bioethanol production from marine biomass alginate by metabolically engineered bacteria.
    Takeda H., et al., Energy Environ. Sci., 4, 2575-2581, 2011.


  • Dynamic changes in the accumulation of metabolites in brackish water clam Corbicula japonica associated with alternation of salinity.
    Koyama H., et al., Comp. Biochem. Physiol. B Biochem. Mol. Biol., 181, 59-70, 2015.

  • Arginine-ornithine Antiporter ArcD Controls Arginine Metabolism and Interspecies Biofilm Development of Streptococcus gordonii.
    Sakanaka A., et al., J. Biol. Chem., 290, 21185-21198, 2015.

  • Physiological and genomic features of a novel sulfur-oxidizing gammaproteobacterium belonging to a previously uncultivated symbiotic lineage isolated from a hydrothermal vent.
    Nunoura T., et al., PLoS One, 9:e104959, 2014.

  • Campylobacter jejuni pdxA affects flagellum-mediated motility to alter host colonization.
    Asakura H., et al., PLoS One, 8:e70418, 2013.

  • Homozygous and heterozygous GH transgenesis alters fatty acid composition and content in the liver of Amago salmon (Oncorhynchus masou ishikawae).
    Sugiyama M., et al., Biol. Open, 1, 1035-1042, 2012.

  • Cytotoxic Mechanism of Selenomethionine in Yeast.
    Kitajima T., et al., J. Biol. Chem., 287, 10032-10038, 2012.

Flux Analysis

  • Quantification of folate metabolism using transient metabolic flux analysis.
    Tedeschi PM., et al., Cancer Metab., 3:6, 2015.

  • Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma.
    Makinoshima H., et al., J. Biol. Chem., 290, 17495-17504, 2015.

  • Suppression of Microbial Metabolic Pathways Inhibits the Generation of the Human Body Odor Component Diacetyl by Staphylococcus spp.
    Hara T., et al., PLoS One, 9:e111833, 2014

  • Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.
    Mitsuishi Y., et al., Cancer Cell, 22, 66-79, 2012.

  • Metabolomic profiling rationalized pyruvate efficacy in cybrid cells harboring MELAS mitochondrial DNA mutations.
    Kami K., et al., Mitochondrion, 12, 644-653, 2014.

  • Functional modules, structural topology, and optimal activity in metabolic networks.
    Resendis-Antonio O., et al., PLoS Comput. Biol., 8:e1002720, 2012.

  • Depiction of metabolome changes in histidine-starved Escherichia coli by CE-TOFMS.
    Ohashi Y., et al., Mol. Biosyst, 4, 135-147, 2008.