What are “metabolic parameters”?
Metabolic parameters enable researchers to better understand cellular status such as bioenergetics, oxidative stress, mitochondrial function, etc. The metabolic parameters that are featured in the report include adenylate energy charge, an indicator of intracellular energy status; Fischer’s Ratio, an indicator of liver function; LP Ratio, an indicator of mitochondrial function; and total amount of various amino acids. These parameters can only be calculated when the absolute concentrations of metabolites are available.
What sample types can be analyzed?
Mainly cultured cells, animal tissues and blood.
Is there a minimum order requirement?
We accept a minimum of 6 samples for C-SCOPE. Bulk discount is available depending on the number of samples. Please contact us for details.
Can you quantify the concentration of metabolites?
C-SCOPE reports quantitative concentration values for all target metabolites.
What are the benefits of knowing the concentration?
By knowing the concentration, the following can be performed:
- Comparison between different metabolites
- Addition or subtraction of certain metabolites (e.g., for calculation of total amino acids or branched chain amino acids, etc.)
- Comparison of data from different batches
Thus, making it possible to calculate metabolic parameters and integrate the results with past data.
What are the metabolites covered by C-SCOPE?
Please refer to our Annotation List for the lineup of measurable metabolites.
Is fatty acid metabolism included in the analysis?
Fatty acids are not included in the C-SCOPE analysis as they are lipophilic metabolites. However, combining it with LC-TOFMS Analysis allows fatty acids and acylcarnitines to be added to the measurement targets.
How is C-SCOPE different from Basic Scan?
C-SCOPE provides highly sensitive analysis of 116 metabolites involved in energy metabolism and has the ability to quantify the concentration of these target metabolites.
How much difference in sensitivity does CE-QqQMS have compared to CE-TOFMS?
The sensitivity is increased by a factor of 10 to 1,000, depending on the metabolite.
How much does the analysis cost?
The price will vary depending on the test scale, number of samples and inclusion of any optional analyses. Please contact your local distributor. If your local distributor is not listed here, please contact us.
How do I request for analysis?
Please refer to our Service Flow.
Please check here for information on the required sample volume, study design and report.